Figure 2. Activation of CagA and intracellular actin condensation.

Figure 2

Activation of CagA and intracellular actin condensation. Translocation is mediated by the cag TFSS (a); activation is dependent by a membrane-associated host kinase (b, c) that phosphorylate CagA at multiple sites; small GTP-binding proteins may be involved in recruitment of the N-WASP and Arp 2/3 complex for cortical actin polymerization (d).

From: Chapter 31, The cag Pathogenicity Island

Cover of Helicobacter pylori
Helicobacter pylori: Physiology and Genetics.
Mobley HLT, Mendz GL, Hazell SL, editors.
Washington (DC): ASM Press; 2001.
Copyright © 2001, ASM Press.

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