Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death.

This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities.

The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the

• Nature, clinical manifestations, diagnosis, and epidemiology of malaria.
• Biology of the malaria parasite and its vector.
• Prospects for developing malaria vaccines and improved treatments.
• Economic, social, and behavioral factors in malaria control.

Contents

• COMMITTEE FOR THE STUDY ON MALARIA PREVENTION AND CONTROL: STATUS REVIEW AND ALTERNATIVE STRATEGIES
• Preface
• Acknowledgments
• 1. Conclusions and Recommendations
  • DEFINING THE PROBLEM
  • THE REPORT
  • CONCLUSIONS AND RECOMMENDATIONS
• 2. Background
  • MALARIA AS A DISEASE
  • Clinical Aspects
  • Immunity
  • Role of Genetics
  • DIAGNOSIS
  • THE PARASITE
  • THE MOSQUITO
  • THE ENVIRONMENT
  • EPIDEMIOLOGY
  • MALARIA CONTROL
  • BIBLIOGRAPHY
• 3. Overview
  • PRE-COLUMBIAN HISTORY
  • MALARIA IN AMERICA
  • DISCOVERY OF QUININE
  • DISCOVERY OF THE MALARIA PARASITE AND ITS LIFE CYCLE
  • MALARIA AND THE MILITARY
  • MALARIA CONTROL
  • ERADICATION
  • U.S. AND INTERNATIONAL SUPPORT FOR MALARIA ACTIVITIES
  • REFERENCES
• 4. Clinical Medicine and the Disease Process
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 5. Diagnostic Tests
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 6. Parasite Biology
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 7. Vector Biology, Ecology, and Control
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 8. Drug Discovery and Development
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 9. Vaccines
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 10. Epidemiologic Approaches to Malaria Control
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 11. Economics of Malaria Control
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• 12. Social and Behavioral Aspects of Malaria
  • WHERE WE WANT TO BE IN THE YEAR 2010
  • WHERE WE ARE TODAY
  • RESEARCH AGENDA
  • REFERENCES
• Appendix A PARADIGMS
• Appendix B DISSENTING OPINION
• Glossary

Funding for this study was provided by the Agency for International Development, the U.S. Army Medical Research and Development Command, and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine.