Contents

• COMMITTEE ON MALARIA VACCINES
• BOARD ON INTERNATIONAL HEALTH
• BOARD ON HEALTH PROMOTION AND DISEASE PREVENTION
• Acknowledgments
• 1. Summary
  • PROJECT CHARGE
  • ORGANIZATION OF THE REPORT
  • FINDINGS AND RECOMMENDATIONS
• 2. Malaria: The Deteriorating Situation
  • GLOBAL EXTENT, CAUSATIVE AGENT, AND MODE OF TRANSMISSION OF MALARIA
  • HEALTH IMPACT OF MALARIA ON THE U.S. POPULATION
  • ECONOMIC AND DEVELOPMENT IMPACT OF MALARIA
  • CURRENT STRATEGIES FOR MALARIA CONTROL
  • THE RATIONALE FOR DEVELOPING A MALARIA VACCINE
  • GOALS AND TARGET POPULATIONS FOR MALARIA VACCINES
• 3. Malaria Vaccines: The Elements for Success Are Moving into Place
• 4. Current Obstacles to Development
  • THE SCIENCE
  • COORDINATION
• 5. Solutions for Science
• 6. Solutions for Coordination
  • PREREQUISITES FOR SUCCESS
  • MODELS FOR COORDINATION AND LEADERSHIP
  • IMPLEMENTING COORDINATION
  • THE NEXT STEPS
• References
• Appendix Workshop Agenda

This study was supported in part by the MacArthur Foundation, the Rockefeller Foundation, the Burroughs Wellcome Fund, the National Institutes of Health, and the Navy Medical Research Institute. The views presented in this report are those of the Committee on Malaria Vaccines and are not necessarily those of the funding organizations.

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy's 1863 congressional charter responsibility to be an adviser to the federal government and its own initiative in identifying issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine.