NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Annual Reviews Collection [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov.
Figure 7
GPCR-induced activation of PLC-γ by PTKs. An agonist-occupied GPCR induces the exchange of GDP for GTP on the α subunit of Gs or Gi and the subsequent dissociation of the α subunit from the membrane-associated Gβγ dimer. The GTP-bound αs or αi subunit activates c-Src by inducing its autophosphorylation, and the phosphorylated enzyme then associates with and phosphorylates a receptor PTK. The phosphorylated receptor PTK provides a structural scaffold for the assembly of a signaling complex that includes PLC-γ (see Figure 4).
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- Figure 7, [GPCR-induced activation of PLC-γ by...]. - Annual Reviews CollectionFigure 7, [GPCR-induced activation of PLC-γ by...]. - Annual Reviews Collection
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