In this report, the subcommittee recommends an approach to assess potential reproductive and developmental toxicity from exposures to substances encountered in workplaces operated by the United States Navy.

Contents

• THE NATIONAL ACADEMIES
• SUBCOMMITTEE ON REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY
• COMMITTEE ON TOXICOLOGY
• BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
• COMMISSION ON LIFE SCIENCES
• OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
• OTHER REPORTS OF THE COMMITTEE ON TOXICOLOGY
• Preface
• Abbreviations
• Summary
  • CONCLUSIONS AND RECOMMENDATIONS
• 1. Introduction
  • SUBCOMMITTEE'S TASK
  • ORGANIZATION OF THE REPORT
• 2. The Evaluative Process: Part I. Assessing the Available Data
  • PRINCIPLES AND OBJECTIVES
  • GENERAL DESCRIPTION
  • DETAILS OF THE EVALUATIVE PROCESS
• 3. The Evaluative Process: Part II. Integration of Toxicity and Exposure Information
  • INTERPRETATION OF TOXICITY DATA
  • QUANTITATIVE EVALUATION
  • SUMMARY
• 4. Incomplete or Insufficient Data Sets
  • PRINCIPLES TO MINIMIZE RISK
  • PRACTICAL APPLICATION
  • REDUCING UNCERTAINTY
• 5. Recommendations
  • GENERAL RECOMMENDATIONS
  • RESEARCH RECOMMENDATIONS
• References
• Appendixes
  • Appendix A. Application of the Recommended Evaluative Process to Specific Chemicals
  • Appendix B. Ascertaining Information on the Reproductive and Developmental Toxicity of Agent Exposures
  • Appendix C. Human Study Designs
  • Appendix D. Experimental Animal and In Vitro Study Designs

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.