Endpoints typically measured at terminal phase of pregnancy
Preimplantation loss
Implantation site
Corpora lutea
Resorptions and fetal death
Live offspring with malformations and variations
Affected (nonlive and malformed) conceptus
Fetal weight
Endpoints that can be measured postnatally
Stillbirth
Offspring viability (birth, within the first week, weaning, etc.)
Offspring growth (birth, postnatal)
Physical landmarks of development (e.g., vaginal opening, palanopreputial separation)
Neurobehavioral development and function (actual enpoints measured depend on the function or organ system being studied)
Reflex development
Locomotor development
Motor activity
Sensory function
Social-reproductive behavior
Cognitive function
Neuropathology and brain weight
Reproductive system development and function
Vaginal opening
Onset of estrus
Balano-preputial separation
Ovarian cyclicity
Quantitation of ovarian primordial follicles
Sperm measures (e.g., morphology, motility, number)
Fertility
Pregnancy outcome
Other organ system function (e.g., renal, cardiovascular)
From: Appendix D, Experimental Animal and In Vitro Study Designs
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