Physical Examination

Vital signs: Sitting, standing and recumbent blood pressure and pulse, height, weight, percent body fat (based on sum of four skinfolds), temperature

Clinical evaluation: Review of systems, significant interval history, summary of defects and diagnoses, recommendations, qualifying information

Dental exam results

Vision (full exam): Corrected and uncorrected distant and near vision, each eye and binocular; color vision, depth perception, heterophorias, intraocular pressure; only near and distant acuity tested for comparison participants

Audiometry: 500, 1,000, 2,000, 3,000, 4,000, 6,000, 8,000 Hz for each ear

ECG: Consultant interpretation

Pulmonary function test: Standard spirometry test

Dual energy X-ray absorptiometry (DEXA) scan

Exercise tolerance test (85% max): Bruce Protocol - heart rate and blood pressure recorded under the following conditions: every minute for 5 minutes in supine position, every minute for 3 minutes standing, immediately after running in place and every minute for 3 minutes, every minute for 3 minutes at each of the following grade/mph: 10/1.7, 12/2.5, 14/3.4, 16/4.2, 18/5.0, 20/5.5, 22/6.0, and during recovery every minute until return to baseline, total exercise time, reason test terminated early

Chest X-ray interpretation

Proctosigmoidoscopy interpretation

Colonoscopy interpretation

Mammogram consultant interpretation

Pelvic exam/Pap smear; pathology report

Comprehensive Laboratory Analysis

Hematology: WBC, RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, platelet count, RDW, reticulocyte count, differential (neutrophils, lymphocytes, monocytes, basophils, eosinophils)

Chemistry panel: Glucose, BUN, uric acid, creatinine, total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, glutamyltransferase, sodium, potassium, chloride, phosphorus, calcium, magnesium, carbon dioxide, total protein

Serum iron: Iron, ferritin, total iron binding capacity, transferrin, transferrin saturation

Lipid profile: Cholesterol, triglyceride, VLDL, HDL, LDL, Chol/HLD ratio

Urinalysis: pH, specific gravity, color, appearance, protein, glucose, ketone, blood, bilirubin, urobilinogen, nitrite, leukocyte esterase, WBC, RBC, epithelial cells, mucus

Ionized calcium profile: Ionized calcium, ionized calcium at 7.40

SPE panel: Total protein, albumin, alpha 1, alpha 2, beta, gamma, A/G ratio

Immunoglobulin panel: IGG, IGA, IGM, IGE

Serology: Hepatitis A total, hepatitis B surface antigen, hepatitis B surface antibody, hepatitis C antibody, RPR, CRP, anti-HIV

Thyroid function tests

Personal Medical History

Self-report of personal medical history, checklist review of medical problems, hospitalizations

Medical Records Obtained from the Johnson Space Center Medical Clinics, Private Physicians and Hospitals

Acute and chronic medical events, diagnoses, medical procedures, treatment, medications, recommendations

Lifestyle Questionnaire

Marital status and history, family medical history, reproductive history, smoking history, alcohol use, exercise and weight patterns, pilot experience, hormone use (women only)

Death Records

Death certificate, hospitalization records, and autopsy reports, if available, are obtained

Post-Flight Medical Debrief (astronauts only)

Twenty-five page questionnaire/interview: self-report of medical events that occurred during flight, inflight exercise, medications use, quality of sleep, habitability issues, recovery symptoms post-flight