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Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.
Molecular Biology of the Cell. 4th edition.
Show detailsCells have to organize themselves in space and interact mechanically with their environment. They have to be correctly shaped, physically robust, and properly structured internally. Many of them also have to be able to change their shape and move from place to place. All of them have to be able to rearrange their internal components as they grow, divide, and adapt to changing circumstances. All these spatial and mechanical functions are developed to a very high degree in eucaryotic cells, where they depend on a remarkable system of filaments called the cytoskeleton (Figure 16-1).
The cytoskeleton pulls the chromosomes apart at mitosis and then splits the dividing cell into two. It drives and guides the intracellular traffic of organelles, ferrying materials from one part of the cell to another. It supports the fragile plasma membrane and provides the mechanical linkages that let the cell bear stresses and strains without being ripped apart as the environment shifts and changes. It enables some cells, such as sperm, to swim, and others, such as fibroblasts and white blood cells, to crawl across surfaces. It provides the machinery in the muscle cell for contraction and in the neuron to extend an axon and dendrites. It guides the growth of the plant cell wall and controls the amazing diversity of eucaryotic cell shapes.
The varied functions of the cytoskeleton center on the behavior of three families of protein molecules, which assemble to form three main types of filaments. Each type of filament has distinct mechanical properties and dynamics, but certain fundamental principles are common to them all. These principles provide the basis for a general understanding of how the cytoskeleton works.
In this chapter, we begin by describing the three main types of filaments, the basic principles underlying their assembly and disassembly, and their individual peculiarities. We then describe how other proteins interact with the three main filament systems, enabling the cell to establish and maintain internal order, to shape and remodel its surface, to move organelles in a directed manner from one place to another, and—when appropriate—to move itself to new locations. The wonderfully coordinated actions of the cytoskeleton in cell division are discussed separately, in Chapter 18.
- The Self-Assembly and Dynamic Structure of Cytoskeletal Filaments
- How Cells Regulate Their Cytoskeletal Filaments
- Molecular Motors
- The Cytoskeleton and Cell Behavior
- References
- The Cytoskeleton - Molecular Biology of the CellThe Cytoskeleton - Molecular Biology of the Cell
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