Figure 9. Alignment of human and Caenorhabditid Di-Ras subfamily predicted N-termini.

Figure 9Alignment of human and Caenorhabditid Di-Ras subfamily predicted N-termini.

GTPase domain sequences are in blue, established mammalian sequences in black, the inferred DRN-1 N-terminal extension in purple, and ambiguous further N-terminal extension in gray. Dileucine repeats are bolded. Di-Ras3 (ARHI, Noey2) has an N-terminal extension containing three dileucine motifs. Assuming a non-AUG initiation codon, transcript C54A12.4.2, predicted by RNAseq, aligns with upstream genomic sequence in C. briggsae (Cbr) and C. brenneri (Cbn), all of which could start with a dileucine repeat. Hypothetical translation of the overlapping transcript C54A12.4.1 also contains a dileucine, but it precedes a stop codon and so it may be a computational artifact. Detailed analysis of the drn-1 gene structure may resolve these questions.

From: Small GTPases

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WormBook: The Online Review of C. elegans Biology [Internet].
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Copyright: © 2016 David J. Reiner and Erik A. Lundquist.

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