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WormBook: The Online Review of C. elegans Biology [Internet]. Pasadena (CA): WormBook; 2005-2018.
In cis-splicing, the U1 snRNP base pairs with the 5’ splice site, and U2 snRNP base pairs with the branchpoint near the 3’ splice site. The intron is excised and the two exons are spliced together. In trans-splicing there is no 5’ splice site on the pre-mRNA for U1 snRNP binding. Instead, the 5’ splice site is provided by the donor SL snRNP, which may base pair with a sequence in the outron, the region of the pre-mRNA between the 5’ cap and the trans-splice site. The SL exon is then spliced to the first exon on the pre-mRNA. CBC: nuclear cap binding complex.
From: Trans-splicing and operons in C. elegans
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