INTRODUCTION

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Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Feb.

Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet].

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1INTRODUCTION

Ingenol mebutate gel (Picato) is a topical cream for which the manufacturer is requesting listing as a second-line treatment in patients with actinic keratosis (AK) who have failed or are intolerant to 5-fluorouracil (5-FU). Ingenol mebutate gel is available in two strengths for different administration sites:

0.015% for lesions on the face and scalp
0.05% for lesions on the trunk or extremities.

The recommended treatment course for ingenol mebutate 0.015% is once daily for three days, while the recommended treatment course for ingenol mebutate 0.05% is once daily for two days. Ingenol mebutate is flat-priced at $383.00 per pack for both the 0.015% and 0.05% strengths. Each pack lasts for one treatment course.

1.1. Cost Comparison Table

The comparator treatments presented in the table below have been deemed the appropriate comparators by clinical experts. Comparators may be recommended (appropriate) practice, versus actual practice. Comparators are not restricted to drugs, but may be devices or procedures. Costs are manufacturer list prices, unless otherwise specified.

Table 1

Cost Comparison Table for Ingenol Mebutate Gel.

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Bookshelf ID: NBK195590

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Ingenol Mebutate (Picato): Topical Treatment of Non-hyperkeratotic, Non-hypertrophic Actinic Keratosis in Adults [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Feb. 1, INTRODUCTION.