FIGURE 21.5. Biosynthesis of N-glycans and addition of N-glycans to -Asn-X-Ser/Thr- residues in newly synthesized glycoproteins in the yeast endoplasmic reticulum (ER).

FIGURE 21.5

Biosynthesis of N-glycans and addition of N-glycans to -Asn-X-Ser/Thr- residues in newly synthesized glycoproteins in the yeast endoplasmic reticulum (ER). Individual steps in the biosynthesis pathway from dolichol phosphate and the structure of dolichol are shown. Steps in the biosynthesis identified by mutants in yeast are shown as genes designated as ALG or SEC. The structure of the intermediate Glc3Man9GlcNAc2-P-P-Dol, which is common to yeast and mammals, is shown.

Symbol Key: FIGURE 21.5. Biosynthesis of N-glycans and addition of N-glycans to -Asn-X-Ser/Thr- residues in newly synthesized glycoproteins in the yeast endoplasmic reticulum (ER).

Download Teaching Slide (PPT, 796K)

From: Chapter 21, Fungi

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.