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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
%20at%20room%20temperature%20over%2048%20hr%20in%20(A)%20DPBS%20pH%207.4%20buffer%2C%20(b)%20Lipoxygenase%20UV-Vis%20assay%20buffer%20of%201M%20HEPES%20pH%207.3%2C%20(C)%20pH%202%20buffer%20and%20(D)%20pH%2010%20buffer.&p=BOOKS&id=190602_ml351f3.jpg "Click on image to zoom")
Figure 1Stability of ML351 measured as percent composition of probe molecule in aqueous solution (contains 20 % acetonitrile) at room temperature over 48 hr in (A) DPBS pH 7.4 buffer, (b) Lipoxygenase UV-Vis assay buffer of 1M HEPES pH 7.3, (C) pH 2 buffer and (D) pH 10 buffer
Results showed good stability of ML351 in different types of buffers.
- PMCPubMed Central citations
- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.[J Med Chem. 2014]Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, et al. J Med Chem. 2014 May 22; 57(10):4035-48. Epub 2014 May 13.
- Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.[J Med Chem. 2010]Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, et al. J Med Chem. 2010 Oct 28; 53(20):7392-404.
- Review Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase.[Probe Reports from the NIH Mol...]Review Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase.Luci D, Jameson JB II, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- A potent and selective inhibitor targeting human and murine 12/15-LOX.[Bioorg Med Chem. 2016]A potent and selective inhibitor targeting human and murine 12/15-LOX.Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, et al. Bioorg Med Chem. 2016 Mar 15; 24(6):1183-90. Epub 2016 Jan 21.
- Review Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO).[Probe Reports from the NIH Mol...]Review Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO).Rai G, Jadhav A, Schultz L, Kenyon V, Leister W, Simeonov A, Holman TR, Maloney DJ. Probe Reports from the NIH Molecular Libraries Program. 2010
- Figure 1, Stability of ML351 measured as percent composition of probe molecule i...Figure 1, Stability of ML351 measured as percent composition of probe molecule in aqueous solution (contains 20 % acetonitrile) at room temperature over 48 hr in (A) DPBS pH 7.4 buffer, (b) Lipoxygenase UV-Vis assay buffer of 1M HEPES pH 7.3, (C) pH 2 buffer and (D) pH 10 buffer - Probe Reports from the NIH Molecular Libraries Program
- An inhibitor of the Cdc2-like kinase 4 (Clk4) - Probe Reports from the NIH Molec...An inhibitor of the Cdc2-like kinase 4 (Clk4) - Probe Reports from the NIH Molecular Libraries Program
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