FIGURE 16.8. The heparan sulfate chain consists of different domains that vary in the extent of modification by sulfation and epimerization.

FIGURE 16.8

The heparan sulfate chain consists of different domains that vary in the extent of modification by sulfation and epimerization. (NS) N-sulfated domains; (NA/NS) domains of variable sulfation; (NA) N-acetylated domains. Modified domains make up binding sites for various ligands, for example, fibroblast growth factors (FGFs) and antithrombin.

Symbol Key: FIGURE 16.8. The heparan sulfate chain consists of different domains that vary in the extent of modification by sulfation and epimerization.

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From: Chapter 16, Proteoglycans and Sulfated Glycosaminoglycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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