FIGURE 16.7. Heparan sulfate biosynthesis involves copolymerization of N-acetylglucosamine and glucuronic acid residues.

FIGURE 16.7

Heparan sulfate biosynthesis involves copolymerization of N-acetylglucosamine and glucuronic acid residues. A series of modification reactions including sulfation and epimerization of glucuronic acid to iduronic acid occurs; chain polymerization and modification are thought to occur simultaneously. (PAPS) 3′-phosphoadenyl–5′-phosphosulfate, the high-energy donor of sulfate groups.

Symbol Key: FIGURE 16.7. Heparan sulfate biosynthesis involves copolymerization of N-acetylglucosamine and glucuronic acid residues.

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From: Chapter 16, Proteoglycans and Sulfated Glycosaminoglycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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