FIGURE 16.10. After secretion, cell-surface heparan sulfate proteoglycans can be processed further.

FIGURE 16.10

After secretion, cell-surface heparan sulfate proteoglycans can be processed further. Heparanase cleaves the HS chain, liberating oligosaccharides and bound ligands. The Sulfs remove sulfate groups from subsets of 6-O-sulfated N-sulfated glucosamine units and can modulate growth factor signaling.

Symbol Key: FIGURE 16.10. After secretion, cell-surface heparan sulfate proteoglycans can be processed further.

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From: Chapter 16, Proteoglycans and Sulfated Glycosaminoglycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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