Table 4. [Treatment of Manifestations in Individuals with Donnai-Barrow Syndrome]. - GeneReviews®

Manifestation/ Concern	Treatment	Considerations/Other
Diaphragmatic hernia	Surgical repair ¹	Postoperative assessment of respiratory function to determine if there is ↑ risk for long-term respiratory problems
Omphalocele	Surgical repair ¹
Myopia	Corrective lenses	Peripheral laser photocoagulation may minimize risk of retinal detachment resulting from high myopia.
Retinal detachment	Treatment per ophthalmologist
Hearing loss	Hearing aid &/or cochlear implant per ENT
Seizures	Standardized treatment w/AEDs by experienced neurologist	Many different AEDs may be effective; none has been shown effective specifically for this disorder.
Hypovitaminoses	Supplementation as needed	Monitoring of serum vitamins A & D (25-hydroxyvitamin D)

Manifestation/
Concern

Treatment

Considerations/Other

Diaphragmatic hernia

Surgical repair ¹

Postoperative assessment of respiratory function to determine if there is ↑ risk for long-term respiratory problems

Omphalocele

Surgical repair ¹

Myopia

Corrective lenses

Peripheral laser photocoagulation may minimize risk of retinal detachment resulting from high myopia.

Retinal
detachment

Treatment per ophthalmologist

Hearing loss

Hearing aid &/or cochlear implant per ENT

Seizures

Standardized treatment w/AEDs by experienced neurologist

Many different AEDs may be effective; none has been shown effective specifically for this disorder.

Hypovitaminoses

Supplementation as needed

Monitoring of serum vitamins A & D (25-hydroxyvitamin D)

From: Donnai-Barrow Syndrome

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