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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
%20at%20room%20temperature%20over%2048%20hr%20in%20(A)%20DPBS%20buffer%20pH%207.4%2C%20(B)%20assay%20buffer%2C%20(C)%20pH%202%20and%20(D)%20pH%2010%20buffers%3B%20and%20(E)%205%20mM%20solution%20of%20Glutathione%20over%2024%20hr.&p=BOOKS&id=179831_ml367f4.jpg "Click on image to zoom")
Figure 1Stability of ML367 measured as percent composition of probe molecule in aqueous solution (contains 20 % acetonitrile) at room temperature over 48 hr in (A) DPBS buffer pH 7.4, (B) assay buffer, (C) pH 2 and (D) pH 10 buffers; and (E) 5 mM solution of Glutathione over 24 hr.
ML367 was observed to be relatively stable in these test buffers. The slight decrease in area over time in the assay and pH 10 buffers were observed to be a result of compound precipitation. No other peaks observed via LC/MS were formed over 48 hr.
- PMCPubMed Central citations
- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
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- Figure 1, Stability of ML367 measured as percent composition of probe molecule i...Figure 1, Stability of ML367 measured as percent composition of probe molecule in aqueous solution (contains 20 % acetonitrile) at room temperature over 48 hr in (A) DPBS buffer pH 7.4, (B) assay buffer, (C) pH 2 and (D) pH 10 buffers; and (E) 5 mM solution of Glutathione over 24 hr. - Probe Reports from the NIH Molecular Libraries Program
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