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Williams M, Todd GD, Roney N, et al. Toxicological Profile for Manganese. Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2012 Sep.
Figure 3-13Physiologically Based Pharmacokinetic Model Structure Describing Manganese Tissue Kinetics in Adult Monkeys and Humans*
*In each tissue department, the amount of bound manganese is in equilibrium with the assumed binding capacity (Btissue) and free manganese. Tissue-binding processes are controlled by association and dissociation rate constants (ka, kd). Free manganese (Mnf) moves in the blood throughout the body and is stored in each tissue as bound manganese (Mnb). Influx and efflux diffusion rate constants (Kin and kout) control preferential increases in free manganese in brain regions. QP, QC, and Qtissue refer to pulmonary ventilation, cardiac output, and tissue blood flows.
Source: Schroeter et al. 2011
- Figure 3-13, Physiologically Based Pharmacokinetic Model Structure Describing Ma...Figure 3-13, Physiologically Based Pharmacokinetic Model Structure Describing Manganese Tissue Kinetics in Adult Monkeys and Humans* - Toxicological Profile for Manganese
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