Structured Abstract

Contents

• Preface
• Acknowledgments
• Introduction
  • Background
• Methods
  • Identifying New Evidence From Published Studies
  • Identifying New Evidence From the U.S. Food and Drug Administration, Health Canada, and Medicines and Healthcare Products Regulatory Agency (MHRA) (UK)
  • Identifying New Evidence From Experts and Expert Opinion
  • Check for Qualitative and Quantitative Signals
  • Determining Priority for Updating a CER
  • Summary Dissemination of Reports to AHRQ
  • Peer Review and Public Commentary
• Results
  • Time To Complete the Surveillance Reports
  • Assessment Findings
• Discussion
  • Conclusions
• References
• Abbreviations
• Appendix A Examples of “Low,” “Medium,” and “High” Assessments
• Appendix B Methods for Identifying Regulatory Information or Safety Alerts

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No.: 290-2007-10062-I (Southern California EPC), 290-2007-10059-I (Ottawa EPC). Prepared by: The RAND Corporation, Southern California Evidence-based Practice Center, Santa Monica, CA, University of Ottawa Evidence-based Practice Center, Ottawa, Canada

Suggested citation:

Newberry SJ, Ahmadzai N, Motala A, Tsertsvadze A, Maglione M, Ansari MT, Hempel S, Tsouros S, Schneider Chafen J, Shanman R, Skidmore B, Moher D, Shekelle, PG. Surveillance and Identification of Signals for Updating Systematic Review: Implementation and Early Experience. Methods Research Report (Prepared by the RAND Corporation, Southern California Evidence-based Practice Center under Contract No. 290-2007-10062-I and University of Ottawa Evidence-based Practice Center 290-2007-10059-I). AHRQ Publication No. 13-EHC088-EF. Rockville, MD: Agency for Healthcare Research and Quality; June 2013. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the Southern California and University of Ottawa Evidence-based Practice Centers (EPCs) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2007-10062-I [Southern California EPC] and 290-2007-10059-I [University of Ottawa EPC]). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

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