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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 12Comparison of the prior art with HCV Core probe ML322
| Compound Name | Structure | PubChem CID | Probe Source | Present in MLSMR | PubMed ID (PMID) | HCV Core IC50 (μM) | Huh7.5 CC50 (μM) | QPCR EC50 |
|---|---|---|---|---|---|---|---|---|
| Probe ML322 |
 | 49800087 | SRIMSC Synthesis | No | Manuscript in preparation | 8.4 | >30 | T1 = NA; T2 = 1.8 μM; TCID50 = 2 nM |
| SL201 |
 | 16759727 | CMLD (Boston University) CMLD003452 | Yes MLS000829710 | 20035614 (Ref [17], Kota 2010) | 9.3 | 320 | T1 = 20.8 μM; T2 = 36.3 μM |
| SL205 |
 | None | CMLD Synthesis | No | 19896376 (Ref [12], Wei 2009; (Compound 16) | 2.0 | >320 | T1 = 4.9 μM; T2 = 0.7 μM |
| SL209 |
 | None | CMLD Synthesis | No | 19896376 (Ref [12], Wei 2009; (Compound 17) | 1.4 | 127 | T1 = 2.3 μM; T2 = 3.2 μM |
| SL210 |
 | None | CMLD Synthesis | No | 19896376 (Ref [12], Wei 2009; (Compound 18) | 2.0 | 5.3 | T1 = 3.8 μM; T2 = 3.0 μM |
- Core as a novel viral target for hepatitis C drugs.[Viruses. 2010]Core as a novel viral target for hepatitis C drugs.Strosberg AD, Kota S, Takahashi V, Snyder JK, Mousseau G. Viruses. 2010 Aug; 2(8):1734-1751. Epub 2010 Aug 20.
- Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells.[J Virol. 2015]Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells.Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U. J Virol. 2015 Mar; 89(6):3200-8. Epub 2014 Dec 31.
- A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host.[Virol J. 2016]A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host.Sa-Ngiamsuntorn K, Wongkajornsilp A, Phanthong P, Borwornpinyo S, Kitiyanant N, Chantratita W, Hongeng S. Virol J. 2016 Apr 5; 13:59. Epub 2016 Apr 5.
- Review Assemble and Interact: Pleiotropic Functions of the HCV Core Protein.[Hepatitis C Viruses: Genomes a...]Review Assemble and Interact: Pleiotropic Functions of the HCV Core Protein.Polyak SJ, Klein KC, Shoji I, Miyamura T, Lingappa JR. Hepatitis C Viruses: Genomes and Molecular Biology. 2006
- Review Probe Development Efforts to Identify Novel Inhibitors of ABHD10.[Probe Reports from the NIH Mol...]Review Probe Development Efforts to Identify Novel Inhibitors of ABHD10.Zuhl AM, Mohr JT, Speers AE, Bachovchin DA, Berlin JM, Spicer T, Fernandez-Vega V, Brown SJ, Ferguson J, Fu GC, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Table 12, Comparison of the prior art with HCV Core probe ML322 - Probe Reports ...Table 12, Comparison of the prior art with HCV Core probe ML322 - Probe Reports from the NIH Molecular Libraries Program
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