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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 1AddAB Inhibitors PubChem Summary (Cycle 13)
| Stage | Assay Name | Tested | Active | PubChem AID |
|---|---|---|---|---|
| HTS (run by Scripps: MLSMR Liquids) | Primary AddAB Inhibition Assay | 326,136 | 937 | 435030 |
| Bacteria Viability 1X Counterscreen | 326,136 | 895 | 449728 | |
| AddAB 3X Confirmation Assay | 885 | 564 | 488942 | |
| RecBCD 3X Counterscreen | 885 | 650 | 488955 | |
| Bacteria Viability 3X Counterscreen | 885 | 308 | 488956 | |
| AddAB 3X Dose Response | 225 | 7 | 492959 | |
| Bacteria Viability 3X Dose Response Counterscreen, E. Coli V3065 | 225 | 1 | 492958 | |
| RecBCD3X Dose Response Counterscreen | 225 | 0 | 492957 | |
| SAR (run by Scripps: powders) | AddAB 3X Dose Response (Round 1) | 12 | 3 | 504677 |
| AddAB 3X Dose Response (Round 2) | 6 | 3 | 651942 | |
| Bacteria Viability 3X Dose Response Counterscreen, E. Coli V3065 | 12 | 0 | 504678 | |
| RecBCD 3X Dose Response Counterscreen (Round 1) | 12 | 0 | 504679 | |
| RecBCD 3X Dose Response Counterscreen (Round 2) | 6 | 0 | 651944 | |
| Bacteria Viability 3X Dose Response Counterscreen, E. Coli V66 | 6 | 0 | 651943 | |
| SAR (run by Gerry Smith’s Lab: powders) | AddAB Nuclease Assay (100 μM) | 54 | 16 | 602422 |
| AddAB Nuclease Assay (IC50) | 31 | 13 | 602421 | |
| RecBCD Nuclease (50 μM) | 12 | 8 | 623922 | |
| RecBCD Nuclease (100 μM) | 54 | 27 | 623921 | |
| RecBCD Nuclease (IC50) | 33 | 14 | 623920 | |
| RecBCD Chi Cutting (50 μM) | 49 | 16 | 623937 | |
| RecBCD Chi Cutting (IC50) | 15 | 8 | 623942 | |
| RecBCD Hfr Recombination Assay (100 μM) | 50 | 7 | 623919 | |
| RecBCD Hfr Recombination Assay (IC50) | 7 | 7 | 623918 | |
| E. Coli Viability (Hfr) (100 μM) | 50 | 1 | 623916 | |
| E. Coli Viability (Hfr) (IC50) | 8 | 1 | 623917 | |
| recBCD Deletion p(addAB) & p(recA) Ecoli Hfr Cross (20 μM) | 11 | 1 | 623956 | |
| recBCD Deletion p(addAB) & p(recA) Ecoli Hfr Cross (100 μM) | 3 | 2 | 623954 |
See also Summary AID 449731.
- PubChem SubstanceRelated PubChem Substances
- Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.[ACS Chem Biol. 2012]Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez Vega V, Bannister TD, Hodder P, Smith GR. ACS Chem Biol. 2012 May 18; 7(5):879-91. Epub 2012 Mar 23.
- Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.[Mol Microbiol. 2008]Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.Amundsen SK, Fero J, Hansen LM, Cromie GA, Solnick JV, Smith GR, Salama NR. Mol Microbiol. 2008 Aug; 69(4):994-1007.
- Dual nuclease and helicase activities of Helicobacter pylori AddAB are required for DNA repair, recombination, and mouse infectivity.[J Biol Chem. 2009]Dual nuclease and helicase activities of Helicobacter pylori AddAB are required for DNA repair, recombination, and mouse infectivity.Amundsen SK, Fero J, Salama NR, Smith GR. J Biol Chem. 2009 Jun 19; 284(25):16759-16766. Epub 2009 Apr 24.
- Review The processing of double-stranded DNA breaks for recombinational repair by helicase-nuclease complexes.[DNA Repair (Amst). 2010]Review The processing of double-stranded DNA breaks for recombinational repair by helicase-nuclease complexes.Yeeles JT, Dillingham MS. DNA Repair (Amst). 2010 Mar 2; 9(3):276-85. Epub 2010 Jan 29.
- Review ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE).[Probe Reports from the NIH Mol...]Review ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE).Bannister TD, Wang H, Abdul-Hay SO, Masson A, Madoux F, Ferguson J, Mercer BA, Schurer S, Zuhl A, Cravatt BF, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Table 1, AddAB Inhibitors PubChem Summary (Cycle 13) - Probe Reports from the NI...Table 1, AddAB Inhibitors PubChem Summary (Cycle 13) - Probe Reports from the NIH Molecular Libraries Program
- Homo sapiens androgen-induced basic leucine zipper (AIBZIP), mRNAHomo sapiens androgen-induced basic leucine zipper (AIBZIP), mRNAgi|18702324|ref|NM_130898.1|Nucleotide
- Larimus fasciatus isolate 11625 recombination activating protein 1 (RAG1) gene, ...Larimus fasciatus isolate 11625 recombination activating protein 1 (RAG1) gene, partial cdsgi|1967464626|gb|MT879901.1|Nucleotide
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