Table 5. [X-Linked Agammaglobulinemia: Treatment of Manifestations]. - GeneReviews®

Manifestation/Concern	Treatment	Considerations/Other
Acute infections	Antibiotic treatment that is at least twice as long as that used in otherwise healthy persons	Generous use of antibiotics is recommended & treatment should be given w/o unnecessary delay.
Risk of bacterial infections	Prophylactic antibiotics are used in some centers for prevention of bacterial infections.	Amoxicillin combined w/clavulanic acid (an inhibitor of beta-lactamase enzyme) can be used, or alternatively sulfamethoxazole & trimethoprim. Ciprofloxacin may be used as a third option.
Vaccines, apart from live vaccines, are recommended. ¹	Protective antibodies will not be generated but cellular immune responses likely will.
Risk assoc w/live vaccines	Children w/XLA should only be given inactivated polio vaccine (IPV).	The sibs of children w/XLA should also be given IPV rather than oral polio vaccine (OPV) to avoid infecting their affected sib w/live polio virus.

Manifestation/Concern

Treatment

Considerations/Other

Acute infections

Antibiotic treatment that is at least twice as long as that used in otherwise healthy persons

Generous use of antibiotics is recommended & treatment should be given w/o unnecessary delay.

Risk of bacterial infections

Prophylactic antibiotics are used in some centers for prevention of bacterial infections.

Amoxicillin combined w/clavulanic acid (an inhibitor of beta-lactamase enzyme) can be used, or alternatively sulfamethoxazole & trimethoprim. Ciprofloxacin may be used as a third option.

Vaccines, apart from live vaccines, are recommended. ¹

Protective antibodies will not be generated but cellular immune responses likely will.

Risk assoc w/live vaccines

Children w/XLA should only be given inactivated polio vaccine (IPV).

The sibs of children w/XLA should also be given IPV rather than oral polio vaccine (OPV) to avoid infecting their affected sib w/live polio virus.

From: X-Linked Agammaglobulinemia

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