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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 7Heat Map Comparisons of Differential Gene Expression by Salinomycin
Gene expression profile of prior art, salinomycin. HMLE_sh_ECad (shECad) (A) and HMLE_sh_GFP (sh_GFP) (B) were treated with DMSO or salinomycin (Sal). Genes that had significantly different expression (p≤ 0.005) and had at least 1.5-fold change in expression were plotted in a heat map. After Sal treatment, 683 and 1,021 genes were altered in HMLE_sh_ECad or HMLE_sh_GFP line, respectively. Of those, 262 genes overlapping were identified in both conditions (C). Comparing HMLE_sh_ECad selective compounds ML245, salinomycin, and CID 50904149 (Analog), 84 genes were identified to be regulated by all three compounds.
- PMCPubMed Central citations
- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
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- Review Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1.[Probe Reports from the NIH Mol...]Review Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1.Carmody L, Germain A, Morgan B, VerPlank L, Fernandez C, Forbeck E, Ting A, Feng Y, Perez J, Dandapani S, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Review Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3.[Probe Reports from the NIH Mol...]Review Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3.Carmody L, Germain A, Morgan B, VerPlank L, Fernandez C, Feng Y, Perez J, Dandapani S, Munoz B, Palmer M, et al. Probe Reports from the NIH Molecular Libraries Program. 2010
- Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.[J Biomol Screen. 2012]Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells.Carmody LC, Germain AR, VerPlank L, Nag PP, Muñoz B, Perez JR, Palmer MA. J Biomol Screen. 2012 Oct; 17(9):1204-10. Epub 2012 Aug 30.
- Identification of a selective small molecule inhibitor of breast cancer stem cells.[Bioorg Med Chem Lett. 2012]Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain AR, Carmody LC, Morgan B, Fernandez C, Forbeck E, Lewis TA, Nag PP, Ting A, VerPlank L, Feng Y, et al. Bioorg Med Chem Lett. 2012 May 15; 22(10):3571-4. Epub 2012 Jan 25.
- Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.[Bioorg Med Chem Lett. 2013]Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, et al. Bioorg Med Chem Lett. 2013 Mar 15; 23(6):1834-8. Epub 2013 Jan 16.
- Figure 7, Heat Map Comparisons of Differential Gene Expression by Salinomycin - ...Figure 7, Heat Map Comparisons of Differential Gene Expression by Salinomycin - Probe Reports from the NIH Molecular Libraries Program
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