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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 2ML218 selectively blocks T-type Ca2+ currents without affecting voltage-gated Na+ and K+ currents in DRG neurons
A. ML218 (1μM) reversibly blocks the T-type Ca2+ currents elicited by depolarizing steps to −30mV from a Vh of −100mV (n=3). Recordings were made in the presence of TTX (1μM) and TEA (20mM). B. ML218 (1μM) has no effect on TTX-sensitive Na+ currents elicited by depolarization to −30mV from Vh of −100mV (n=3). C. ML218 (1μM) has no effect on outward K+ currents elicited by depolarization to 70mV from a Vh of −60mV (n=3) after blocking Ca2+ and Na+ channels.
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- The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.[ACS Chem Neurosci. 2011]The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.Xiang Z, Thompson AD, Brogan JT, Schulte ML, Melancon BJ, Mi D, Lewis LM, Zou B, Yang L, Morrison R, et al. ACS Chem Neurosci. 2011 Dec 21; 2(12):730-742.
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- Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle.[J Cell Sci. 2013]Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle.Harraz OF, Welsh DG. J Cell Sci. 2013 Jul 1; 126(Pt 13):2944-54. Epub 2013 Apr 23.
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