Mesotheliomas limited to other organs are extremely rare. About 120 cases of pericardial mesothelioma have been reported¹⁶²; this represents the most frequent primary malignant tumor of the pericardium and accounts for half of them.¹⁶³ It has been reported as occurring at any age; there is a 3:1 male predominance.¹⁶⁴ The tumor produces signs of pericardial effusion, often bloody, leading to cardiac tamponade and/or constriction of the vena cava and great vessels. Local spread as well as metastases involving the pleura, lung, mediastinum, or distant organs occurs in half the cases.¹⁶⁵ Survival time is usually less than 6 months, although two patients treated with surgery and radiotherapy survived 1 and 5 years, respectively.¹⁶³ The role of asbestos exposure has not been systematically explored, although it was strongly suggested in one report.¹⁶⁶

Malignant mesothelioma of the tunica vaginalis testis (“adenomatoid tumor”) presents as a scrotal mass, often associated with a hydrocele. In a review of 24 cases, median age was 61 (range 21 to 78) years, and asbestos exposure was documented in 6.¹⁶⁷