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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 8Selective cytotoxicity of ML223 for CBF leukemia cell lines
The graph on the left shows % change of ATP contents in ME-1 (black line) and HL-60 (blue line) cells after treatment with ML223 at the indicated concentrations. ME-1 contains the CBFB-MYH11 fusion gene and HL-60 does not. The table on the right shows IC50 values for the listed cell lines. The ATP contents were measured by a luciferase based cell viability assay with −100% as 100% cell killing13.
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- Immunohistochemical analysis of CBFbeta-SMMHC protein reveals a unique nuclear localization in acute myeloid leukemia with inv(16)(p13q22).[Am J Surg Pathol. 2006]Immunohistochemical analysis of CBFbeta-SMMHC protein reveals a unique nuclear localization in acute myeloid leukemia with inv(16)(p13q22).Zhao W, Claxton DF, Medeiros LJ, Lu D, Vadhan-Raj S, Kantarjian HM, Nguyen MH, Bueso-Ramos CE. Am J Surg Pathol. 2006 Nov; 30(11):1436-44.
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- RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.[Cancer Res. 2007]RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.Cammenga J, Niebuhr B, Horn S, Bergholz U, Putz G, Buchholz F, Löhler J, Stocking C. Cancer Res. 2007 Jan 15; 67(2):537-45.
- Type J CBFbeta/MYH11 transcript in the M4Eo subtype of acute myeloid leukemia.[Hematology. 2003]Type J CBFbeta/MYH11 transcript in the M4Eo subtype of acute myeloid leukemia.Trnková Z, Peková S, Bedrlíková R, Záková D, Zemanová Z, Polák J, Michalová K, Cermák J, Schwarz J. Hematology. 2003 Apr; 8(2):115-7.
- Review Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.[Adv Exp Med Biol. 2017]Review Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Castilla LH, Bushweller JH. Adv Exp Med Biol. 2017; 962:229-244.
- Figure 8, Selective cytotoxicity of ML223 for CBF leukemia cell lines - Probe Re...Figure 8, Selective cytotoxicity of ML223 for CBF leukemia cell lines - Probe Reports from the NIH Molecular Libraries Program
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