Figure 13. Chemical genetic analysis of active compounds on RTG pathway.

Figure 13Chemical genetic analysis of active compounds on RTG pathway

A) RTG pathway in yeast (From Liu and Butow, 2006 [23]). B) Flow cytometry analysis of CIT2-GFP expression in the rtg3 knockout mutant with the treatment of 30μM compounds as well as 0.22μM rapamycin. The GFP fold change was calculated using DMSO treatment as negative control. C) LacZ enzyme activity analysis of CIT2-LacZ fold change was calculated using DMSO treatment as negative control.

From: Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway

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