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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 3SAR of Scaffold 6 Diphenyl Carbinol
 | |||||
|---|---|---|---|---|---|
| Entry | R/Ar group | VU ID | CID | SID | AVE IC50 (μM, n of 2) |
| 1 | H | VU0424409 | 46926611 | 99432372 | 2.34E-04 |
| 2 | n-Bu | VU0424410 | 46926613 | 99432373 | 1.53E-05 |
| 3 | cyclopropyl | VU0424411 | 46926615 | 99432374 | 1.12E-05 |
| 4 | -- (ketone) | VU0424454 | 46926627 | 99432381 | 2.75E-04 |
| 5 | CH3 | VU0424455 | 46926629 | 99432382 | 2.95E-04 |
| 6 | cyclopentyl | VU0424456 ML227 | 46926631 | 99432383 | 8.83E-07 |
| 7 | cyclohexyl | VU0424457 | 46926633 | 99432384 | 1.68E-06 |
| 8 | 4-CH3OPh | VU0424458 | 46926635 | 99432385 | Inactive |
| 9 | 4-FPh | VU0424459 | 46926637 | 99432386 | 7.75E-05 |
| 10 | R or S cyclohexyl (peak A) | VU0433663 | 49791887 | 103147637 | 5.70E-07 |
| 11 | R or S cyclohexyl (peak B) | VU0433664 | 49791888 | 103147638 | 1.13E-06 |
| 12 | RorScyclopentyl (peak A) | VU0433665 | 49791889 | 103147639 | 3.36E-07 |
| 13 | RorScyclopentyl (peak B) | VU0433666 | 49791890 | 103147640 | 4.13E-07 |
| 14 | i-Pr | VU0433667 | 49791891 | 103147641 | 4.05E-06 |
| 15 | cyclobutyl | VU0433794 | 49791893 | 103147642 | 4.00E-06 |
| 16 | CF3 | VU0433795 | 49791895 | 103147643 | 3.10E-05 |
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