U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

Cover of Probe Reports from the NIH Molecular Libraries Program

Probe Reports from the NIH Molecular Libraries Program [Internet].

Show details

Table 7Analogues with R1 – R4 substitution patterns in combination

EntrySID/CID*
Image ml230fu24.jpg
Efflux Assay Potency (μM) mean (n = # replicates)Selectivity B1:G2Potentiation Assays
R1R2R3R4ABC B1ABC G2ABC B1ABC G2
nIC50 μM (% Res)anIC50 μM (% Res)aCR50 (μM)TD50 (μM)TD50/ CR50CR50 (μM)TD50 (μM)TD50/ CR50
1SID88095709Sphenyl2-furylHCO-3- furan54.65 (112)40.13 (98)35.80.555.52toxic0.3118.3059
CID44640177
2SID99376136S3-Cl-phenyl2-furylHCOCH310.80 (113)20.56 (127)1.40.0817.602320.58>100174
CID46912089
3SID99376137S3-MeO-phenyl2-furylHCOCH311.64 (66)21.9 (121)0.90.3249.301551.18>10085
CID46912090
4SID99376134S4-Me-phenyl2-furylHCH2-3- furan18.7 (114)22.67 (64)3.30.3512.50toxic1.6857.8034
CID46912091
5SID87557810SphenylmethylmethylCO-3- furan51.63 (33)52.18 (94)0.7NTNTNTNT
CID44629743
6SID97301789S3-MeO-phenylmethylmethylCH2-3- furan350.0040.21 (82)233.20.02>10054950.09>1001176
CID46245505
a

Percent Response;

*

S = synthesized; P = purchased; NT = not tested

Views

  • Cite this Page
  • PDF version of this page (1.2M)

Related information

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...