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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Table 3Summary of modifications for R1
| Entry | SID/CID | * |
 | Efflux Assay Potency (μM) mean (n = # replicates) | Selectivity B1:G2 | Potentiation Assays | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R1 | ABC B1 | ABC G2 | ABC B1 | ABC G2 | ||||||||||
| n | IC50 μM (% Res)a | n | IC50 μM (% Res)a | CR50 (μM) | TD50 (μM) | TD50/ CR50 | CR50 (μM) | TD50 (μM) | TD50/ CR50 | |||||
| 1 | SID88095709 | S | phenyl | 5 | 4.65 (112) | 4 | 0.13 (98) | 35.8 | 0.55 | 5.52 | toxic | 0.31 | 18.30 | 59 |
| CID44640177 | ||||||||||||||
| 2 | SID99376135 | S | t-butyl | 1 | 3.31 (89) | 1 | 1.97 (102) | 1.7 | NT | NT | NT | NT | ||
| CID46912088 | ||||||||||||||
| 3 | SID99361154 | S | 2- thiophene | 1 | 8.42 (107) | 2 | 1.56 (100) | 5.4 | NT | NT | NT | NT | ||
| CID46905003 | ||||||||||||||
| 4 | SID99361155 | S | 2-furan | 2 | 1.70 (84) | 2 | 2.35 (99) | 0.7 | 0.19 | 1.93 | toxic | 1.21 | >100 | 83 |
| CID46905000 | ||||||||||||||
| 5 | SID92123918 | S | 3-Cl- phenyl | 4 | 6.42 (112) | 5 | 2.55 (84) | 2.5 | 0.53 | 8.53 | toxic | 1.38 | 10.80 | toxic |
| CID45105077 | ||||||||||||||
| 6 | SID99361153 | S | 4-Cl- phenyl | 1 | 41.54 (79) | 2 | 1.89 (101) | 22.0 | NT | NT | NT | NT | ||
| CID46904995 | ||||||||||||||
| 7 | SID99361150 | S | 2-MeO- phenyl | 1 | 5.57 (124) | 2 | 2.76 (104) | 2.0 | NT | NT | NT | NT | ||
| CID46905004 | ||||||||||||||
| 8 | SID92764890 | S | 3-MeO- phenyl | 4 | 7.40 (89) | 5 | 2.26 (78) | 3.3 | 0.47 | 5.52 | toxic | 1.00 | >100 | 100 |
| CID45281176 | ||||||||||||||
| 9 | SID93619266 | S | 4-MeO- phenyl | 4 | 3.45 (51) | 4 | 0.89 (68) | 3.9 | 5.77 | >100 | 17 | 0.76 | >100 | 131 |
| CID45489721 | ||||||||||||||
| 10 | SID99361151 | S | 3-Me- phenyl | 1 | 3.45 (123) | 1 | 0.58 (103) | 6.0 | NT | NT | NT | NT | ||
| CID46905007 | ||||||||||||||
| 11 | SID99361152 | S | 4-Me- phenyl | 1 | 11.27 (109) | 1 | 5.19 (102) | 2.2 | NT | NT | NT | NT | ||
| CID46904998 | ||||||||||||||
| 12 | SID88095710 | S | 3-(2-furyl)- phenyl | 4 | 3.98 (100) | 5 | 0.93 (82) | 4.3 | NT | NT | NT | NT | ||
| CID44640180 | ||||||||||||||
- a
Percent Response;
- *
S = synthesized; P = purchased; NT = not tested
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- Table 3, Summary of modifications for R1 - Probe Reports from the NIH Molecular ...Table 3, Summary of modifications for R1 - Probe Reports from the NIH Molecular Libraries Program
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