Table 4. [CPIC Recommended Therapeutic Use of Allopurinol by HLA-B Genotype (2015)]. - Medical Genetics Summaries

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Pratt VM, Scott SA, Pirmohamed M, et al., editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

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Table 4.

CPIC Recommended Therapeutic Use of Allopurinol by HLA-B Genotype (2015)

Genotype test results	Example of diplotypes	Phenotype	Therapeutic recommendations
Negative for HLA-B58:01*	(X/X)^b	Low or reduced risk of allopurinol-induced SCAR	Use allopurinol per standard dosing guidelines
Positive for HLA-B58:01*	58:01/(X)^b 58:01/58:01	Significantly increased risk of allopurinol-induced SCAR	Allopurinol is contraindicated

: The strength of therapeutic recommendations is “strong” (3, 4).
SCAR, severe cutaneous adverse reaction, CPIC, Clinical Pharmacogenetics Implementation Consortium
^b *X, any HLA-B genotype other than HLA-B*58:01
: This table adapted from (4) with standardized terminology (6).

From: Allopurinol Therapy and HLA-B*58:01 Genotype

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Dean L, Kane M. Allopurinol Therapy and HLA-B*58:01 Genotype. 2013 Mar 26 [Updated 2020 Dec 9]. In: Pratt VM, Scott SA, Pirmohamed M, et al., editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-. Table 4. [CPIC Recommended Therapeutic Use of Allopurinol by HLA-B Genotype (2015)].
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