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Sickle Cell Acute Painful Episode: Management of an Acute Painful Sickle Cell Episode in Hospital. Manchester (UK): National Institute for Health and Clinical Excellence (NICE); 2012 Jun. (NICE Clinical Guidelines, No. 143.)
Sickle Cell Acute Painful Episode: Management of an Acute Painful Sickle Cell Episode in Hospital.
Show detailsReview Question 1. Pharmacological management
Table 37. Evidence table for Perlin et al (1994) (PDF, 138K)
Table 38. Evidence table for Wright et al (1992) (PDF, 100K)
Table 39. Evidence table for Griffin et al (1994) (PDF, 98K)
Table 40. Evidence table for Bartolucci et al (2009) (PDF, 112K)
Table 41. Evidence table for Al-Jama et al (1999) (PDF, 118K)
Table 42. Evidence table for Van Beers et al (2007) (PDF, 136K)
Table 43. Evidence table for Gonzalez et al (1991) (PDF, 125K)
Table 44. Evidence table for Quari et al (2007) (PDF, 98K)
Table 45. Evidence table for Adam-Graves et al (1997) (PDF, 122K)
Table 46. Evidence table for Orringer et al (2001) (PDF, 128K)
Table 47. Evidence table for Teuscher et al (1989) (PDF, 91K)
Table 48. Evidence table for Hardwick et al (1999) (PDF, 97K)
Table 49. Evidence table for Adawy et al (2005) (PDF, 137K)
Table 50. Evidence table for Head et al (2010) (PDF, 87K)
Table 51. Evidence table for Jacobson et al (1997) (PDF, 94K)
Table 52. Evidence table for Gladwin et al (2011) (PDF, 126K)
Table 53. Evidence table for Weiner et al (2003) (PDF, 109K)
Table 54. Evidence table for Grisham & Vichinsky (1996) (PDF, 95K)
Table 55. Evidence table for Robieux et al (1992) (PDF, 109K)
Table 56. Evidence table for Zipursky et al (1992) (PDF, 126K)
Review question 2. Non-pharmacological management
Review question 3. Clinical signs and symptoms of acute complications
Table 58. Evidence table for Kopecky et al (2004) (PDF, 107K)
Table 59. Evidence table for Finkelstein et al (2007) (PDF, 99K)
Table 60. Evidence table for Buchanan et al (2005) (PDF, 129K)
Table 61. Evidence table for Styles et al (2000) (PDF, 99K)
Table 62. Evidence table for Lewing et al (2011) (PDF, 101K)
Table 63. Evidence table for Audard et al (2010) (PDF, 123K)
Table 64. Evidence table for Baumgartner et al (1989) (PDF, 115K)
Table 65. Evidence table for (Berger et al 2009) (PDF, 90K)
Table 66. Evidence table for Buchanan et al (1978) (PDF, 96K)
Table 67. Evidence table for Ander et al (1997) (PDF, 96K)
Table 68. Evidence table for Pollack et al (1991) (PDF, 87K)
Table 69. Evidence table for Bernard et al (2008) (PDF, 107K)
Table 70. Evidence table for Chapman et al (2004) (PDF, 78K)
Review question 4. Settings and skills for managing an acute painful episode
Table 71. Evidence table for Raphael et al (2008) (PDF, 85K)
Table 72. Evidence table for Benjamin et al (2000) (PDF, 95K)
Table 73. Evidence table for Frei-Jones et al (2009) (PDF, 118K)
Table 74. Evidence table for Adam-Graves et al (2008) (PDF, 90K)
Table 75. Evidence table for Jamison & Brown (2008) (PDF, 115K)
Table 76. Evidence table for Mitchell et al (2002) (PDF, 114K)
Table 77. Evidence table for Montanez & Berland (2002) (PDF, 109K)
Review question 5. Information and support needs of patients and their carers during an acute painful sickle cell episode
Table 79. Evidence table for Alleyne & Thomas (1994) (PDF, 119K)
Table 80. Evidence table for Booker et al (2006) (PDF, 104K)
Table 81. Evidence table for Johnson (2003) (PDF, 92K)
Table 82. Evidence table for Maxwell et al (1999) (PDF, 119K)
Table 83. Evidence table for Maxwell & Streetly (1998) (PDF, 115K)
Table 84. Evidence table for Harris et al (1998) (PDF, 96K)
Table 85. Evidence table for Mitchell et al (2007) (PDF, 96K)
Table 86. Evidence table for Waters & Thomas (1995) (PDF, 97K)
Table 87. Evidence table for Lattimer et al (2010) (PDF, 89K)
Table 88. Evidence table for Murray & May (1988) (PDF, 105K)
GRADE profiles
Review Question 1. Pharmacological management
Table 89. GRADE profile for primary analgesia (PDF, 347K)
Table 90. GRADE profile for pharmacological management of the underlying sickling process (PDF, 366K)
Review question 2. Non-pharmacological management
See full guideline for GRADE profile
Review question 3. Clinical signs and symptoms of acute complications
See full guideline for GRADE profile
Review question 4. Settings and skills for managing an acute painful episode
See full guideline for GRADE profile
Review question 5. Information and support needs of patients and their carers during an acute painful sickle cell episode
No GRADE profile was completed. See full guideline for key themes matrix.
Forest plots
Review question 1. How should an acute painful sickle cell episode be managed using pharmacological interventions?
Figure 3. Forest plot of analgesic use in children treated with ketorolac vs. placebo
Critical appraisal checklist for a questionnaire study
Download PDF (138K)
- Pharmacological management
- Non-pharmacological management
- Clinical signs and symptoms of acute complications
- Settings and skills for managing an acute painful episode
- Information and support needs of patients and their carers during an acute painful sickle cell episode
- GRADE profiles
- Forest plots
- Critical appraisal checklist for a questionnaire study
- Sickle cell acute painful episode: Evidence Update May 2014: A summary of selected new evidence relevant to NICE clinical guideline 143 'Sickle cell acute painful episode: management of an acute painful sickle cell episode in hospital' (2012)
- Surveillance report 2016 - Sickle cell disease: managing acute painful episodes in hospital (2012) NICE guideline CG143
- Evidence tables - Sickle Cell Acute Painful EpisodeEvidence tables - Sickle Cell Acute Painful Episode
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