Table 2. [Cumulative Risk of Cancers in Peutz-Jeghers Syndrome]. - GeneReviews®

Cancer Site	General Population Risk	Peutz-Jeghers Syndrome
Colorectal	5%	39%	42-46 yrs
Stomach	<1%	29%	30-40 yrs
Small bowel	<1%	13%	37-42 yrs
Breast	12.4%	32%-54%	37-59 yrs
Ovarian (mostly SCTAT)	1.6%	21%	28 yrs
Cervix (adenoma malignum)	<1%	10%	34-40 yrs
Uterine	2.7%	9%	43 yrs
Pancreas	1.5%	11%-36%	41-52 yrs
Testicular (Sertoli cell tumor)	<1%	9%	6-9 yrs
Lung	6.9%	7%-17%	47 yrs

Cancer Site

General Population Risk

Peutz-Jeghers Syndrome

Risk

Mean Age at Diagnosis

Colorectal

39%

42-46 yrs

Stomach

<1%

29%

30-40 yrs

Small bowel

<1%

13%

37-42 yrs

Breast

12.4%

32%-54%

37-59 yrs

Ovarian (mostly SCTAT)

1.6%

21%

28 yrs

Cervix (adenoma malignum)

<1%

10%

34-40 yrs

Uterine

2.7%

43 yrs

Pancreas

1.5%

11%-36%

41-52 yrs

Testicular (Sertoli cell tumor)

<1%

6-9 yrs

Lung

6.9%

7%-17%

47 yrs

From: Peutz-Jeghers Syndrome

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