Table 2.

Risk of Malignancy in Individuals with a Germline BRCA1 or BRCA2 Pathogenic Variant

Cancer TypeGeneral Population RiskRisk for Malignancy 1
BRCA1 BRCA2
Breast 12%55%-72% by age 7045%-69%
Contralateral breast cancer 2% w/in 5 yrs20%-30% w/in 10 yrs; 40%-50% w/in 20 yrs
Ovarian 1%-2%39%-44%11%-17%
Male breast 0.1%1%-2%6%-8%
Prostate 6% by age 69 yrs21% by age 75 yrs;
29% by age 85 yrs		27% by age 75 yrs;
60% by age 85 yrs
Pancreatic 0.5%1%-3%3%-5% by age 70 yrs
Melanoma (cutaneous & ocular) 1.6%Elevated risk

From: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer

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