U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.

Cover of GeneReviews®

GeneReviews® [Internet].

Show details

Table 3.

Cumulative Probability of Cardiac Events by Age

Gene% of Persons with ≥1 Cardiac Event 1 by Age 2
Age 10 yearsAge 20 yearsAge 30 yearsAge 40 yearsAge 50 years
KCNH2 9%29%42%46%49%
KCNQ1 15%32%38%42%44%
SCN5A 7%23%29%37%41%
1.

Cardiac events include syncope, aborted cardiac arrest, and sudden cardiac death.

2.

Studies from the LQTS Registry including individuals with clinical manifestations, 14%-20% probands and family members with a pathogenic variant (most individuals were on treatment; 52%-60% with beta-blockers) [Kutyifa et al 2018]

From: Long QT Syndrome Overview

Copyright © 1993-2024, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.

Views

  • Cite this Page
  • PDF version of this page (547K)

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...