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Excerpt
International standardization of rats was undertaken first by this US/Japan Cooperative Program and subsequently by the International Council for Laboratory Animal Science (ICLAS). These activities have reached a global scale with the ICLAS International Rat Genetic Nomenclature Committee, which met first in 1994 in Sapporo, Japan; second in 1996 in Toulouse, France; and third in 1998 in Halifax, Canada.
Recently, biotechnology has made remarkable progress using transgenic animals, and international collaborative studies have used these animals widely. International harmonization of drug safety data for new drug development is also under way. Therefore, international standardization of the quality of laboratory animals as tools for obtaining reproducible data has become even more important.
Contents
- THE NATIONAL ACADEMIES
- INTERNATIONAL COMMITTEE OF THE INSTITUTE FOR LABORATORY ANIMAL RESEARCH COUNCIL
- INSTITUTE FOR LABORATORY ANIMAL RESEARCH COUNCIL
- COMMISSION ON LIFE SCIENCES
- Preface
- Opening RemarksJudith L. Vaitukaitis.
- Opening RemarksShin-Ichi Ota.
- Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of ResultsAnton M. Allen.
- Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing StandardsLela K. Riley.
- Standardization of Rodent Health Surveillance: Regulation Versus CompetitionWilliam Shek.
- Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory AnimalsToshio Itoh.
- Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and MiceToshiyuki Shibahara.
- Emerging (and Reemerging) Viruses of Laboratory Mice and RatsAbigail L. Smith.
- Emerging Infections as a Cause of ConcernStephen Morse.
- Emerging Diseases in Mice and RatsToshio Itoh.
- Survey of Helicobacter Species in Laboratory Mice and Gerbils in JapanKazuo Goto.
- Genetic Evaluation of Outbred RatsJoseph J. DeGeorge.
- Genetic Evaluation of Outbred Rats from the Breeder’s PerspectiveWilliam J. White.
- Concept for Establishment of Rat Outbred Global Standard StrainsTatsuji Nomura.
- Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry’s PerspectiveNaoko Kagiyama.
- International Harmonization of Laboratory AnimalsHideki Katoh.
- Rat Genetics and ToxicologyMichael F.W. Festing.
- A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse GenomeDabney K. Johnson, Donald A. Carpenter, Cymbeline T. Culiat, Karen A. Goss, Mitchell L. Klebig, Edward J. Michaud, Darla R. Miller, Liane B. Russell, Yun You, and Eugene M. Rinchik.
- Evaluation of Targeted MutationsEugenia Floyd.
- Defining Behavioral Phenotypes in Transgenic and Knockout MiceJacqueline N. Crawley.
- Defining Phenotype in Genetically Engineered MiceNorikazu Tamaoki.
- Development of the Mouse Model Dramatype for Human Clinical BenefitKazunori Nakajima.
- Concluding RemarksTatsuji Nomura.
- Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic FunctionsKazuo Moriwaki.
- INTRODUCTION
- GENETIC POSITION OF ASIAN WILD MICE
- USE OF THE ASIAN WILD-DERIVED RECOMBINATION HOST-SPOT GENE FOR SURVEYING NOVEL GENES THAT DETERMINE SUSCEPTIBILITY TO DIABETES
- USE OF ASIAN WILD-DERIVED MITOCHONDRIA FOR STUDYING MOUSE BEHAVIOR
- USE OF ASIAN WILD-DERIVED CHROMOSOMES FOR DEVELOPING NEW CONSOMIC MOUSE STRAINS
- REFERENCES
- Concluding CommentsJohn Strandberg.
- Concluding CommentsJohn Vandenbergh.
- Appendix A U.S./Japan Meeting
- Appendix B Meeting Participants
This study was supported by Grant No. N01-OD-4-2139 between the National Academies and the National Institutes of Health of the U.S. Department of Health and Human Services.
Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
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