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Schematic structure of STEAP family members. Representation of STEAP1, STEAP2, STEAP3 and STEAP4 proteins and their main cellular and biological functions.

Expression of STEAP proteins and overall survival in prostate cancer patients. The Prostate Adenocarcinoma dataset (51), retrieved from cBioPoral, was stratified into groups with unaltered or overexpression of STEAPs, and different combinations were analyzed for overall survival. A. STEAP1 overexpression (n = 20) versus unaltered expression (n = 58) (p < 0.024). B. STEAP1 overexpression (n =20) versus STEAP4 overexpression (n = 52) (p < 0.017). C. STEAP3 overexpression (n = 5) versus STEAP4 overexpression (n = 52) (p < 0.042). D. STEAP1 overexpression plus STEAP2 overexpression (n = 8) versus unaltered expression (n = 58) (p < 0.907). E. STEAP1 overexpression plus STEAP4 overexpression (n = 11) versus STEAP1 overexpression (n = 20) (p < 0.063). Survival curves plotting fractional survival as a function of time was obtained using GraphPad Prisma 8.0.1.

STEAPs expression with the progression of human prostate cancer using CANCERTOOL software. Violin plots show the expression of STEAPs in non-tumoral tissue (N), primary tumours (PT) and metastatic prostate cancer (M) specimens for Taylor dataset (51). This dataset has a cohort of 179 patients and is the only one with statistical significance for all STEAPs. However, the same results are verified in other dataset: for STEAP1, Grasso dataset (52); for STEAP2, Grasso (52), Tomlins (53) and Varambally (54) datasets; for STEAP4, Grasso (52) and Lapointe (55) dataset. Mean gene expression between the three groups was compared with an ANOVA test.