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StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Registries for Evaluating Patient Outcomes: A User's Guide [Internet]. 3rd edition.

Gliklich RE, Dreyer NA, Leavy MB, editors.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr.

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Uranium Mining in Virginia: Scientific, Technical, Environmental, Human Health and Safety, and Regulatory Aspects of Uranium Mining and Processing in Virginia.

Committee on Uranium Mining in Virginia; Committee on Earth Resources; National Research Council.

Washington (DC): National Academies Press (US); 2011 Dec 19.

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Shaping the Future of IoT with Edge Intelligence: How Edge Computing Enables the Next Generation of IoT Applications.

Sofia RC, Soldatos J, editors.

Abingdon (UK): River Publishers; 2024 Jan.

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Some Industrial Chemicals.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1994. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 60.)

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Sources of Medical Technology: Universities and Industry.

Institute of Medicine (US) Committee on Technological Innovation in Medicine; Rosenberg N, Gelijns AC, Dawkins H, editors.

Washington (DC): National Academies Press (US); 1995.

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Patient Safety: Achieving a New Standard for Care.

Institute of Medicine (US) Committee on Data Standards for Patient Safety; Aspden P, Corrigan JM, Wolcott J, et al., editors.

Washington (DC): National Academies Press (US); 2004.

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Prudent Practices in the Laboratory: Handling and Management of Chemical Hazards: Updated Version.

National Research Council (US) Committee on Prudent Practices in the Laboratory.

Washington (DC): National Academies Press (US); 2011.

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Guide to Hygiene and Sanitation in Aviation. 3rd edition.

Geneva: World Health Organization; 2009.

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Chemical Laboratory Safety and Security: A Guide to Developing Standard Operating Procedures.

Committee on Chemical Management Toolkit Expansion: Standard Operating Procedures; Board on Chemical Sciences and Technology; Division on Earth and Life Studies; National Academies of Sciences, Engineering, and Medicine.

Washington (DC): National Academies Press (US); 2016 Jul 7.

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Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Occupational Exposures in Petroleum Refining; Crude Oil and Major Petroleum Fuels.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1989. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 45.)

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Innovations in Pharmaceutical Manufacturing on the Horizon: Technical Challenges, Regulatory Issues, and Recommendations.

National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Chemical Sciences and Technology; Committee to Identify Innovative Technologies to Advance Pharmaceutical Manufacturing.

Washington (DC): National Academies Press (US); 2021 Feb 24.

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Wood Dust and Formaldehyde.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1995. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 62.)

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Waste Incineration & Public Health.

National Research Council (US) Committee on Health Effects of Waste Incineration.

Washington (DC): National Academies Press (US); 2000.

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Some Organophosphate Insecticides and Herbicides.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2017. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 112.)

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Silica, Some Silicates, Coal Dust and para-Aramid Fibrils.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1997. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 68.)

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Multivariate Statistical Machine Learning Methods for Genomic Prediction [Internet].

Montesinos López OA, Montesinos López A, Crossa J.

Cham (CH): Springer; 2022.

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Registries for Evaluating Patient Outcomes: A User’s Guide [Internet]. 4th edition.

Gliklich RE, Leavy MB, Dreyer NA, editors.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Sep.

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Associations between the use of snus (moist tobacco) or electronic cigarettes and tobacco smoking: A systematic review [Internet].

Stockholm: Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU); 2020 Jun 15. (SBU Policy support, No. 312.)

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Figure 9.25Regulation of the tryptophan operon of Escherichia coli.

Regulation occurs via a repressor-operator system in a similar way to that described for the lactose operon (Figure 9.24) but with the difference that the operon is repressed by the regulatory molecule, tryptophan, which is the product of the biochemical pathway specified by the genes in the operon (see Figure 2.20B). When tryptophan is present, and so does not need to be synthesized, the operon is switched off because the repressor-tryptophan complex binds to the operator. In the absence of tryptophan the repressor cannot attach to the operator, and the operon is expressed.

Assembly of the Transcription Initiation Complex.

Brown TA. Genomes. 2nd edition. Oxford: Wiley-Liss; 2002.
Figure 5-13Regulation of lac operon in E. coli

Structural genes lacZ, lacY, and lacA code for β-galactosidase, β-galactoside permease, and b-galactoside transacetylase, respectively. The physiologic role of lacA is unknown. The lac repressor is product of lacI gene in separate regulatory operon. Transcription of mRNA encoding lacZ, lacY, and lacA is negatively regulated. and binding of lac repressor to operator lacO prevents initiation of transcription at promoter lacP. Inducer binds to lac repressor and inactivates it. Catabolite activator protein (CAP) forms a complex with cyclic AMP, and binding of the complex to a site immediately adjacent to the lac promoter stimulates transcription of the lac operon by RNA polymerase. An expanded diagram of the lac operator-promoter region shows the binding sites for CAP, RNA polymerase, and lac repressor.

Genetics.

Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996.
Figure 9.24Regulation of the lactose operon of Escherichia coli

(A) The operator sequence lies immediately downstream of the promoter for the lactose operon. (B) In the original model for lactose regulation, the lactose repressor is looked on as a simple blocking device that binds to the operator and prevents the RNA polymerase gaining access to the promoter. The three genes in the operon are therefore switched off. This is the situation in the absence of lactose, although transcription is not completely blocked because the repressor occasionally detaches, allowing a few transcripts to be made. Because of this basal level of transcription, the bacterium always possesses a few copies of each of the three enzymes coded by the operon (see Figure 2.20A), probably less than five of each. This means that when the bacterium encounters a source of lactose it is able to transport a few molecules into the cell and split these into glucose and galactose. An intermediate in this reaction is allolactose, an isomer of lactose, which induces expression of the lactose operon by binding to the repressor, causing a change in the conformation of the latter so it is no longer able to attach to the operator. This allows the RNA polymerase to bind to the promoter and transcribe the three genes. When fully induced, approximately 5000 copies of each protein product are present in the cell. When the lactose supply is used up and allolactose is no longer present, the repressor re-attaches to the operator and the operon is switched off. Note that the shapes of the repressor and polymerase structures shown here are purely schematic.

Assembly of the Transcription Initiation Complex.

Brown TA. Genomes. 2nd edition. Oxford: Wiley-Liss; 2002.