Metagenome-assembled genome: ERR912138_bin.7_CONCO... - BioSample

Warning: The NCBI web site requires JavaScript to function. more...

Result Filters

Metagenome-assembled genome: ERR912138_bin.7_CONCOCT_v1.1_MAG

Identifiers: BioSample: SAMEA14085366; SRA: ERS11688498

Organism: uncultured Clostridia bacterium
cellular organisms; Bacteria; Bacillati; Bacillota; Clostridia; environmental samples

Attributes

collection date	2010-01-01
broad-scale environmental context	Host-associated
local-scale environmental context	Human
environmental medium	Digestive system
geographic location	United Kingdom
investigation type	metagenome-assembled genome
isolation source	human gut metagenome
project name	The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate heritability of many microbial taxa and functional modules in the gut microbiome, including those associated with diseases. Moreover, we identified 8 million SNPs in the gut microbiome and observe a high similarity in microbiome SNPs between twins that slowly decreases after decades of living apart. The results shed new light on the genetic and environmental influences on the composition and function of the gut microbiome that could relate to risk of complex diseases.
sample name	ERR912138_bin.7_CONCOCT_v1.1_MAG
ENA-CHECKLIST	ERC000047
ENA-FIRST-PUBLIC	2023-01-03
ENA-LAST-UPDATE	2023-01-03
External Id	SAMEA14085366
INSDC center alias	EBI
INSDC center name	European Bioinformatics Institute
INSDC first public	2023-01-03T00:33:16Z
INSDC last update	2023-01-03T00:33:16Z
INSDC status	public
Submitter Id	ERR912138_bin.7_CONCOCT_v1.1_MAG
assembly quality	Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software	spadesv3.11.1
binning parameters	Default
binning software	CONCOCT v1.1
broker name	EMG broker account, EMBL-EBI
completeness score	80.52
completeness software	CheckM
contamination score	0.67
geographic location (latitude)	51.5
geographic location (longitude)	-0.12
metagenomic source	human gut metagenome
sample derived from	SAMEA3449333
scientific_name	uncultured Clostridia bacterium
sequencing method	Illumina HiSeq 2000
taxonomic identity marker	multi-marker approach

Description: This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run ERR912138 of study ERP010700.