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GM20173 male unaffected Marveld2 sample

Identifiers
BioSample: SAMN00805700; Coriell: GM20173; Coriell: NA20173
Organism
Homo sapiens (human)
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo
Attributes
cell lineGM20173
sexMale
cell typeB-Lymphocyte
family id2449
family rolefather
raceEast Indian
ethnicityPAKISTANI
age60 YR
DNA-IDNA20173
GeneMARVELD2
MutationIVS4+2delTGAG
collectionNIGMS Human Genetic Cell Repository
Tags
DFNB49
Marvel domain-containing protein 2
Deafness autosomal recessive 49
Marveld2
Description

Clinically normal of two affected daughters;affected daughter is GM20172;donor subject is heterozygous for a donor site mutation: a deletion of TGAG at positons 2-5 in the cryptic splice-donor site of IVS4 (IVS4+2delTGAG) of the MARVELD2 (TRIC) gene the mRNA uses the site that introduces 23 bp of intron 4 which results in a premature stop codon (p.K445fsX461)

Submission
Coriell; 2012-03-05
Accession:
SAMN00805700
ID:
805700

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