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Genome Information for Drosophila melanogaster
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1 additional project is a component of the KDM5 binding and kdm5 null mutant differential expression profiling of Drosophila prothoracic gland cells.
kdm5 is an essential gene in Drosophila that has critical developmental roles in the prothoracic gland cells of the larval ring gland. To profile KDM5 binding within these cells and this developmental stage, we performed Targeted DamID (TaDa). By profiling the nearest genes to significant TaDa peaks (FDR < 0.01), we identified 5815 candidate KDM5 target genes. Interestingly, 42% of these candidate KDM5 target genes appear to be conserved across multiple cellular contexts in Drosophila and span many cellular processes for future investigation.
Overall design: Targeted DamID (TaDa) for profiling KDM5 binding in Drosophila prothoracic gland cells
| Accession | PRJNA952686; GEO: GSE229076 |
| Data Type | Epigenomics |
| Scope | Multiisolate |
| Organism | Drosophila melanogaster[Taxonomy ID: 7227] Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora; Drosophila melanogaster |
| Publications | Rogers MF et al., "KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila.", Development, 2023 Nov 1;150(21) |
| Submission | Registration date: 5-Apr-2023
Julie Secombe, Ph.D., Genetics, Albert Einstein College of Medicine |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
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| Sequence data |
| SRA Experiments | 8 |
| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| BioSample | 8 |
| GEO DataSets | 1 |