BioProject

Increasing evidence indicates that gut microbiota plays an important role in cancer progression. More...

Increasing evidence indicates that gut microbiota plays an important role in cancer progression. We have employed RNA-seq or microarray for genome including mRNA, microRNA or circRNA profiling in an gut microbiota -dependent manner, as a discovery platform to identify target genes with the potential to involve in tumor regulation. The deep sequencing analysis reveals regulatory functions of microbiota-mediated circular RNA (circRNA)/microRNA networks that may contribute to cancer progression. Overall design: Gut microbiota regulated mRNAs expression in tumor were measured in tumor samples of xenograft cancer model including germ-free mice with or without fecal microbiota transplantation (FMT) from specific pathogen free (SPF) mice or Probiotics (such as Bifidobacterium). Gut microbiota regulated no-coding RNAs (including circRNA and microRNA) expression in mice blood samples were measured in specific pathogen free (SPF) mice with or without broad-spectrum antibiotics (ABX) treatment, with or without fecal microbiota transplantation (FMT) from specific pathogen free (SPF) mice or Probiotics (such as Bifidobacterium, EcN) into germ-free mice. Less...