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2 additional projects are components of the Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits.
To investigate the role of the hypothalamus in complex traits, we generated ATAC-seq, RNA-seq, and Promoter Focused Capture C to gain insight into the gene regulatory arcitecture contacting promoters in an embryonic stem cell dervived model of hypothalamic neuron differentiation
Overall design: We performed ATAC-seq, RNA-seq, and Promoter Focused Capture C on stages of ESC dervived hypothalamic like neuron differentiation (ESC: day 0; HP: day 12; HN: day 27).
Accession | PRJNA638302; GEO: GSE152090 |
Data Type | Epigenomics |
Scope | Multiisolate |
Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
Publications | Pahl MC et al., "Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits.", Nat Commun, 2021 Nov 19;12(1):6749 |
Submission | Registration date: 9-Jun-2020 Struan Grant and Andrew Wells, Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia |
Relevance | Medical |
Project Data:
Resource Name | Number of Links |
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Sequence data |
SRA Experiments | 14 |
Publications |
PubMed | 1 |
PMC | 1 |
Other datasets |
BioSample | 14 |
GEO DataSets | 1 |