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Genome Information for Homo sapiens
To determine differential gene expression in peripheral blood of asthmatic individuals undergoing allergen inhalation challenge between early responders (ERs) and dual responders (DRs) following allergen inhalation challenge
Overall design: Blood was collected immediately prior to, and two hours after challenge
The change in gene expression (post expression minus pre expression) in ERs was compared with the change in gene expression in DRs using age and sex as covariates
Preprocessing and probeset filtering were applied to the entire dataset (28 CEL files) using the Factor Analysis for Robust MicroArray Summarization (farms) package in R
The Linear Models for MicroArrays (limma) package was used to determine differential gene expression using a Benjamini Hochberg FDR of 10%.
| Accession | PRJNA173271; GEO: GSE40240 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens |
| Publications | Singh A et al., "Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses.", PLoS One, 2013;8(7):e67907 |
| Submission | Registration date: 20-Aug-2012
James Hogg Research Centre, Medicine, University of British Columbia |
| Relevance | Medical |
Project Data:
| Resource Name | Number
of Links |
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| Publications |
| PubMed | 1 |
| PMC | 1 |
| Other datasets |
| GEO DataSets | 2 |
GEO Data Details| Parameter | Value |
|---|
| Data volume, Spots | 904988 |
| Data volume, Processed Mbytes | 18 |
| Data volume, Supplementary Mbytes | 107 |