Effect of depletion of HIF-1α, FACT or RNF20/40 on... (ID 897909) - BioProject

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Accession: PRJNA897909 ID: 897909

Effect of depletion of HIF-1α, FACT or RNF20/40 on gene expression in hypoxia of MCF7 breast cancer cells (human)

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To investigate how HIF-1 recruits FACT and RNF20/40 to mediate histone ubiquitination and facilitate transcription of target genes, we established stable cell lines in which HIF-1, FACT or RNF20/40 has been knocked down by shRNA. More...

Accession	PRJNA897909; GEO: GSE217204
Data Type	Transcriptome or Gene expression
Scope	Multiisolate
Organism	Homo sapiens[Taxonomy ID: 9606] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo; Homo sapiens
Publications	Lyu Y et al., "Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.", Cell Rep, 2024 Apr 23;43(4):113972
Submission	Registration date: 3-Nov-2022 Gregg L. Semenza, ICE, Johns Hopkins University
Relevance	Medical

Project Data:

Resource Name	Number of Links
Sequence data
SRA Experiments	24
Publications
PubMed	1
Other datasets
BioSample	24
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	17

SRA Data Details

Parameter	Value
Data volume, Gbases	102
Data volume, Mbytes	31586

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Effect of depletion of HIF-1α, FACT or RNF20/40 on gene expression in hypoxia of MCF7 breast cancer cells (human)

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