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3 additional projects are components of the SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation.
To investigate how Srcap mutations confer mutant hematopoietic stem and progenitor cells (HSPCs) with selective advantage after exposure to cellular stressors, transplantation and doxorubicin treatment
We established Srcap heterozygous mutant murine model and utilized competitive bone marrow transplantation to assess the transcriptome of donor cells using RNA-seq
Overall design: Transcriptomic profiling of RNA-seq data for isolated donor test (CD45.2+) cells 20 weeks after competitive bone marrow transplantation
| Accession | PRJNA956488; GEO: GSE229865 |
| Data Type | Transcriptome or Gene expression |
| Scope | Multiisolate |
| Organism | Mus musculus[Taxonomy ID: 10090] Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus |
| Publications | Chen CW et al., "SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.", Cell Stem Cell, 2023 Nov 2;30(11):1503-1519.e8 |
| Submission | Registration date: 17-Apr-2023
Baylor College of Medicine |
| Relevance | Model Organism |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 24 |
| Publications |
| PubMed | 1 |
| Other datasets |
| BioSample | 24 |
| GEO DataSets | 1 |