The highly conserved RNA-binding specificity of nu... (ID 862494) - BioProject

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Accession: PRJNA862494 ID: 862494

The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity.

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We performed the high-throughput RNA-SELEX (HTR-SELEX) to determine the RNA-binding specificity of the N proteins of various SARS-CoV-2 variants as well as other β-coronaviruses and showed that N proteins could bind two unrelated sequences, both of which were highly conserved across all variants and species. More...

Accession	PRJNA862494; GEO: GSE209797
Scope	Multiisolate
Organism	Escherichia coli[Taxonomy ID: 562] Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia; Escherichia coli
Publications	Fan S et al., "The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity.", Comput Struct Biotechnol J, 2022;20:5040-5044
Submission	Registration date: 26-Jul-2022 Yan Lab, Department of Biomedical Sciences, City University of Hong Kong
Relevance	Model Organism

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Resource Name	Number of Links
Sequence data
SRA Experiments	72
Publications
PubMed	1
PMC	1
Other datasets
BioSample	72
GEO DataSets	1

GEO Data Details

Parameter	Value
Data volume, Supplementary Mbytes	1

SRA Data Details

Parameter	Value
Data volume, Gbases	4
Data volume, Mbytes	2822

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The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity.

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