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Accession: PRJNA975616 ID: 975616

Single nuclei transcriptomics of human and monkey striatum implicates DNA damage, neuroinflammation, and neurodegeneration signaling in opioid use disorder

The striatum in the brain is involved in various behavioral functions, including reward, and disease processes, such as opioid use disorder (OUD). Further understanding of the role of striatal subregions in reward behaviors and their potential associations with OUD requires molecular identification of specific striatal cell types in human brain. The human striatum contains subregions based on different anatomical, functional, and physiological properties, with the dorsal striatum further divided into caudate and putamen. Both caudate and putamen are associated with alterations in reward processing, formation of habits, and development of negative affect states in OUD. Using single nuclei RNA-sequencing of human postmortem caudate and putamen, we identified canonical neuronal cell types in striatum (e. More...
AccessionPRJNA975616; GEO: GSE233279
TypeUmbrella project
PublicationsPhan BN et al., "Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder.", Nat Commun, 2024 Jan 31;15(1):878
Grants
  • "Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders" (Grant ID DP1 DA046585, National Institute on Drug Abuse)
  • "Integrating primate-rodent cell types and epigenomics to identify conservation in substance addiction" (Grant ID F30 DA053020, National Institute on Drug Abuse)
  • "Delineating the role of serotonin 5-HT2 receptors in opioid use disorders:Development of novel 5-HT2 modulators with translational studies in rodents andprimates" (Grant ID R01 DA047130, National Institute on Drug Abuse)
  • "Molecular rhythm alterations in human post-mortem brain associated with opioid use disorder" (Grant ID R01 DA051390, National Institute on Drug Abuse)
  • "Molecular rhythm alterations in human post-mortem brain associated with opioid use disorder" (Grant ID R01 DA051390, National Institute on Drug Abuse)
SubmissionRegistration date: 23-May-2023
Pfenning Lab, Computational Biology, Carnegie Mellon University
RelevanceSuperseries
Project Data:
Resource NameNumber
of Links
Sequence data
SRA Experiments40
Publications
PubMed1
PMC1
Other datasets
BioSample40
GEO DataSets3
GEO Data Details
ParameterValue
Data volume, Supplementary Mbytes14053
SRA Data Details
ParameterValue
Data volume, Gbases1,556
Data volume, Tbytes0.49
Single nuclei transcriptomics of human and monkey striatum implicates DNA damage, neuroinflammation, and neurodegeneration signaling in opioid use disorder encompasses the following 2 sub-projects:
Project TypeNumber of Projects
Transcriptome or Gene expression2
BioProject
accession
OrganismTitle
PRJNA934272Homo sapiensTranscriptional responses of the human dorsal striatum in opioid use disorder implicates cell type-specifc programs (Pfenning Lab, Computational...)
PRJNA975617Macaca mulattaSingle nucleus RNA-seq of the rhesus macaque nucleus accumbens after chronic morphine exposure (Pfenning Lab, Computational...)

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