This SuperSeries is composed of the SubSeries listed below.
Overall design: Refer to individual Series
| Accession | PRJNA964768; GEO: GSE231406 |
| Type | Umbrella project |
| Publications | - Saeki K et al., "IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs.", Nat Immunol, 2024 Oct;25(10):1928-1942
- Saeki K et al., "IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs.", bioRxiv, 2024 Jul 1;
|
| Submission | Registration date: 1-May-2023
NIH/NICHD |
| Relevance | Superseries |
Project Data:
| Resource Name | Number
of Links |
|---|
| Sequence data |
| SRA Experiments | 72 |
| Publications |
| PubMed | 2 |
| PMC | 1 |
| Other datasets |
| BioSample | 72 |
| GEO DataSets | 6 |
IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs encompasses the following 5 sub-projects:
| Project Type | Number of Projects |
| Epigenomics | 3 |
BioProject
accession | Organism | Title |
|---|
| PRJNA964775 | Mus musculus | Genome-wide profiles of IRF8 and PU.1 bindings, and H3K4me1 and H3K27ac histone marks in wild-type and IRF8-knockout microglia [CHIP-seq] (NIH/NICHD) | | PRJNA964776 | Mus musculus | Genome-wide open chromatin status in WT and IRF8KO microglia [ATAC-seq] (NIH/NICHD) | | PRJNA964777 | Mus musculus | Genome-wide methylated CpG status in WT and IRF8KO microglia [WGBS] (NIH/NICHD) |
|
| Transcriptome or Gene expression | 2 |
BioProject
accession | Organism | Title |
|---|
| PRJNA964778 | Mus musculus | Transcriptome profiles of wild-type, IRF8KO, IRF8cKO, Batf3KO, 5xFAD, and 5xFAD/IRF8KO microglia [RNA-seq] (NIH/NICHD) | | PRJNA964779 | Mus musculus | Single-cell transcriptome profiles of wild-type and IRF8KO microglia [scRNA-seq] (NIH/NICHD) |
|